Metformin promotes cGAS/STING signaling pathway activation by blocking AKT phosphorylation in gastric cancer

The cGAS/STING signaling pathway plays a pivotal role in regulating innate immunity. Emerging novel drugs aim to regulate the anti-tumor immune response by activating anti-diabetic drug metformin has been reported exhibit anti-cancer effect against various types of cancer. However, gastric cancer remains unknown. In our study, we first used bioinformatic analysis detect that is closely related tumor immunity multiple tumors. Next, validated function cell lines. addition, KEGG enrichment showed negatively correlated with PI3K/AKT We further verified activates blocking AKT phosphorylation. Moreover, found regulates mediating transcription factor SOX2. Thus, study indicates suppressing SOX2/AKT and promising potential immunotherapy.